Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]
PF 1022A
CAS: 133413-70-4
Molecular Formula: C52H76N4O12
Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl] - Names and Identifiers
Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl] - Physico-chemical Properties
| Molecular Formula | C52H76N4O12 |
| Molar Mass | 949.2 |
| Density | 1.070±0.06 g/cm3(Predicted) |
| Melting Point | 89-92 °C |
| Boling Point | 1086.6±65.0 °C(Predicted) |
| Solubility | DMSO: ≥ 43 mg/mL |
| pKa | -1.09±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | PF 1022A binds to the latrophilin-like transmembrane receptor important for pharyngeal pumping in nematodes. Furthermore, PF 1022A binds to GABA receptors, which might contribute to the anthelmintic effect. In vitro, PF 1022A shows low activity on embryonation but significantly inhibits egg hatch (10 and 100 μg/mL), whereas albendazole (10 and 100 μg/mL) reveales statistically significant inhibitions of both embryonation and egg hatch. PF 1022A (1-100 μg/mL) completely inhibits larval movement at most examination points. |
Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl] - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.054 ml | 5.268 ml | 10.535 ml |
| 5 mM | 0.211 ml | 1.054 ml | 2.107 ml |
| 10 mM | 0.105 ml | 0.527 ml | 1.054 ml |
| 5 mM | 0.021 ml | 0.105 ml | 0.211 ml |
Last Update：2024-01-02 23:10:35
Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl] - Introduction
PF 1022A is an organic phosphate ester compound with the chemical name (2-hydroxy-4-methylphenyl) bis (2,4, 4-trimethylpentyl) phosphate oxide. It is a colorless to pale yellow liquid that is clear and transparent at room temperature. PF 1022A is widely used in lubricants and rust inhibitors.
The excellent lubricating properties of the PF 1022A make it possible to lubricate a wide range of industrial equipment, machinery and moving parts. It has a very low viscosity, and remains stable at high temperatures, and is not easy to oxidize and decompose. In addition, PF 1022A has excellent corrosion resistance and can be used as a protective coating on metal surfaces to effectively prevent metal rust and corrosion.
PF 1022A is generally synthesized by transesterification. Specifically, PF 1022A can be obtained by transesterification of diphenol with 2,4, 4-trimethylcaprolactone, adding phosphoric acid catalyst, and by reaction and separation and purification steps.
Regarding safety information, PF 1022A is relatively safe under normal use conditions. However, direct contact with skin, eyes and mucous membranes should be avoided during the procedure. If it is taken by mistake or enters the eyes, rinse immediately with plenty of water and seek medical attention as soon as possible. In use should pay attention to good ventilation conditions, avoid inhalation of its steam. At the same time, avoid contact with strong oxidants or strong acids during storage to avoid chemical reactions. It is recommended to refer to the relevant safety technical instructions of the product during use and storage, and follow the correct operating methods and measures.
The excellent lubricating properties of the PF 1022A make it possible to lubricate a wide range of industrial equipment, machinery and moving parts. It has a very low viscosity, and remains stable at high temperatures, and is not easy to oxidize and decompose. In addition, PF 1022A has excellent corrosion resistance and can be used as a protective coating on metal surfaces to effectively prevent metal rust and corrosion.
PF 1022A is generally synthesized by transesterification. Specifically, PF 1022A can be obtained by transesterification of diphenol with 2,4, 4-trimethylcaprolactone, adding phosphoric acid catalyst, and by reaction and separation and purification steps.
Regarding safety information, PF 1022A is relatively safe under normal use conditions. However, direct contact with skin, eyes and mucous membranes should be avoided during the procedure. If it is taken by mistake or enters the eyes, rinse immediately with plenty of water and seek medical attention as soon as possible. In use should pay attention to good ventilation conditions, avoid inhalation of its steam. At the same time, avoid contact with strong oxidants or strong acids during storage to avoid chemical reactions. It is recommended to refer to the relevant safety technical instructions of the product during use and storage, and follow the correct operating methods and measures.
Last Update：2024-04-09 21:11:58
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CAS: 133413-70-4
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 133413-70-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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